SOLVED: 2000 silverado 4.3L V6 has misfire.check engine - Fixya
Re: 2000 silverado 4.3L V6 has misfire.check engine light... Hi! A p0300 code is a random misfire, possible causes: primary and secondary ignition, pcm, sticking valvles, worn injectors. Clogged injectors are pretty common but unfortunately you would have the proper equipment to test these areas safely and accurately.