Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction (heart attacks), stent thrombosis, and ischemic stroke (strokes caused by a blood clot).
Plavix (clopidogrel) Drug class: Antiplatelet Drugs. Clopidogrel (Plavix) is an inexpensive drug used to prevent heart attack, stroke, or other events in people who are at high risk. This drug is more popular than comparable drugs. It is available in brand and generic form. Generic Clopidogrel is covered by most Medicare and insurance plans ...
Antiplatelet drugs and coronary stents. Patients selected for percutaneous coronary intervention (PCI), with the placement of a coronary stent, will require dual antiplatelet therapy with aspirin and either cangrelor, clopidogrel, prasugrel, or ticagrelor. Aspirin therapy should continue indefinitely. Following PCI in patients with stable angina, clopidogrel is recommended in …
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Atrial fibrillation is the most common arrhythmia in the elderly population and is an important cause of stroke. The role of antiplatelet therapy remains controversial. Treatment with aspirin and clopidogrel significantly reduced the rate of stroke in randomised clinical trials. Dual antiplatelet therapy (DAPT) could be an alternative treatment ...
Abstract. The current standard care for acute coronary syndromes is dual antiplatelet therapy combining the COX1 inhibitor aspirin with a drug targeting the P2Y12 receptor, together with anticoagulation during and after early revascularization by percutaneous intervention. In very high-risk patients, glycoprotein (GP) IIb/IIIa antagonists may ...
If one considers first the 18 788 stable survivors of myocardial infarction (87% of which were in trials involving aspirin), allocation to a mean of 27 months of antiplatelet treatment resulted in 36 fewer serious vascular events for every 1000 patients treated—an overall reduction from a risk of 17% in the control group to 13.5% in the ...
We assigned patients with peripheral arterial disease to combination therapy with an antiplatelet agent and an oral anticoagulant agent (target international normalized ratio [INR], 2.0 to 3.0) or ...
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Introduction. Antithrombotic therapy is an essential part of the management of the full spectrum of acute coronary syndromes (ACS). 1 Both antiplatelets and anticoagulants seem to be necessary in the management of ACS (Figures 1 and 2), although the exact proportion of antithrombotic effect that each drug and class should ideally provide remains a matter of ongoing study.
The American College of Cardiology/American Heart Association have published guidelines for antiplatelet therapy in PAD 1:. Antiplatelets are indicated to reduce the risk of myocardial infarction (MI), stroke, and vascular death in individuals with symptomatic atherosclerotic lower extremity PAD, including those with intermittent claudication or chronic …
iv WH ecommendation antiplatelet agents for the prevention of pre-eclampsia Acknowledgements The World Health Organization (WHO) Department of Sexual and Reproductive Health and Research, and the Department of Maternal, Newborn, Child and Adolescent Health, and Ageing gratefully acknowledge the contribution of many individuals and
Aims: To assess the effects of 1- or ≥3-month dual antiplatelet therapy (DAPT) in high bleeding risk (HBR) patients who received biodegradable-polymer sirolimus-eluting stents for complex percutaneous coronary intervention (PCI) and/or acute coronary syndrome (ACS). Conclusion: In HBR patients free from recurrent ischemic events at 1 month, DAPT discontinuation was …
What is antiplatelet therapy? Antiplatelets are a group of medicines that stop blood cells (called platelets) from sticking together and forming a blood clot. Whenever there is an injury in your body, platelets are sent to the site of the injury, where they clump together to form a blood clot. This stops the bleeding in your body.
Aspirin is an antiplatelet agent that probably will be prescribed for the rest of a patient's life, if the patient falls into one of these categories and doesn't have strong reasons not to take it. A second type of antiplatelet agent, technically called a P2Y 12 inhibitor, is usually prescribed for months or years in addition to aspirin.
antiplatelet therapy on mortality associated with intracranial hemorrhage. Ohm et.al. found that elderly patients (age > 50 years) who were receiving antiplatelet therapy (either monotherapy or dual therapy) at the time of their traumatic brain injury (TBI) had a significantly higher mortality rate (23% vs. 9% in the control group, p =0.016) (8).
Two trials have compared 1 month of dual antiplatelet therapy with at least 12 months of dual antiplatelet therapy after PCI with drug-eluting stents. 4,6 The GLOBAL LEADERS trial showed that 1 ...
In general, studies reporting a positive association found ≈25% to 80% increased risk of cardiovascular events in patients treated with a PPI in addition to dual antiplatelet therapy. Interestingly, 2 recent meta-analyses of published studies found no association between PPI use and mortality. 32, 33 A significant association with ...
Drugs. clopidogrel. ticlopidine. Mechanism. blocks ADP-mediated platelet aggregation which decreases Gp IIb/IIIa expression via the P2y12 receptor. via irreversible block of ADP receptors. activated platelets secrete ADP. prevents expression of glycoprotein IIb/IIIa by platelets. inhibits binding of fibrinogen and clot formation.
An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation. They are effective in the arterial circulation where anticoagulants have little effect. [citation needed]They are widely used in primary and …
Over time, numerous antiplatelet agents have been developed with a multitude of indications. Antiplatelet medications divide into oral and parenteral agents, and oral agents subdivide further based on the mechanism of action. Aspirin was the first antiplatelet medication and is a cyclooxygenase inhibitor. Other oral antiplatelet include clopidogrel, ticagrelor, and …
Antiplatelets represent a diverse group of agents that share the ability to reduce platelet activity through a variety of mechanisms. Antithrombotic agents are effective in the secondary prevention of ischemic strokes. Most strokes are caused by a …
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Risk of GI Bleeding With Antiplatelet Therapy and Effect of Gastroprotective Strategies. Aspirin causes direct damage to the gastric epithelium and inhibits prostaglandin production by the gastric mucosa, leading to ulcerations and an estimated 2-fold increased risk of GI bleeding with low-dose aspirin alone. 1 The risk increases with the additional use of …
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acetylsalicylic acid (ASA), better known as aspirin, is the most widely used antiplatelet therapy. ASA acts by inhibiting the synthesis of thromboxane A2. ADP-receptor antagonists/P2Y12 receptor antagonists (clopidogrel and ticlopidine); prasugrel, cangrelor (i.v.) and AZD6140 are in phase III clinical development.